Prenatal Exposure to Perfluoroalkyl Substances and Adiposity in Early and Mid-Childhood

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Prenatal Exposure to Perfluoroalkyl Substances and Adiposity in Early and Mid-Childhood

BACKGROUND Few studies have examined whether prenatal exposure to perfluoroalkyl substances (PFASs) is associated with childhood adiposity. OBJECTIVE We examined associations of prenatal exposure to PFASs with adiposity in early and mid-childhood. METHODS We measured plasma PFAS concentrations in 1,645 pregnant women (median, 9.6 weeks gestation) enrolled in Project Viva, a prospective pre-...

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Early-Life Exposure to Perfluoroalkyl Substances and Childhood Metabolic Function

BACKGROUND Perfluoroalkyl substances (PFASs) are synthetic chemicals that may persist in the environment and in humans. There is a possible association between early-life PFAS exposure and metabolic dysfunction in later life, but data are limited. METHODS We studied 665 mother-child pairs in Project Viva, a Boston, Massachusetts-area cohort recruited 1999-2002. We quantified concentrations of...

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Prenatal Exposure to Perfluoroalkyl Substances and Behavioral Development in Children

BACKGROUND In recent years, prevalence rates of behavioral disorders in children have increased. One factor possibly implied in the etiology of behavioral disorders is exposure to perfluoroalkyl substances (PFASs). The use of PFASs is highly integrated into everyday life, and exposure is ubiquitous. Exposure to PFASs during early life may be particularly harmful, as it represents a critical tim...

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Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood atopic dermatitis: a prospective birth cohort study

BACKGROUND Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been reported to suppress immune function. However, previous studies on prenatal exposure to PFASs and allergic disorders in offspring provided inconsistent results. We aimed to examine the association between prenatal exposure to PFASs and childhood atopic dermatitis (AD) in offspring up to 24 months of age. METHODS A pros...

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Prenatal exposure to perfluoroalkyl substances and the risk of congenital cerebral palsy in children.

Perfluoroalkyl substances (PFASs) are persistent pollutants and endocrine disruptors that may affect fetal brain development. We investigated whether prenatal exposure to PFASs increases the risk of congenital cerebral palsy (CP). The source population for this study includes 83,389 liveborn singletons and mothers enrolled in the Danish National Birth Cohort during 1996-2002. We identified 156 ...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 2017

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp246